MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1 dependent TGF-β signaling
TGF-β induced MLL4 methlytransferase recruiment
☕️Professional Summary
Timothy En Haw Chan is a scientist working on understanding epigenetics regulation in cancer and cell signaling, focuses on the interplay of external stimulus to cellular epigenetic regulation. Expertise in information curation, data analysis and synthesis idea. Passionate to summarize discoveries, biotech industry development and communicating science in biomedical field. He lived in Malaysia, Taiwan, Germany and traveled to more than 60 countries. Other than research, he is a contributing writer/columnist and science outreach educator.
Education
PhD Biology
2018-09-01
2026-03-31
Max Planck IMPRS-IEM PhD Program & University of Freiburg, Germany
MS Biomedical Sciences
2016-09-01
2018-08-15
Chang Gung University, Taiwan
BSc Biomedical Sciences
2012-09-01
2016-06-28
Chang Gung University, Taiwan
Interests
Epigenetics
Cancer Biology
Signaling Transduction
Synthetic Biology
📚 My Research 🧬
Elucidating interplays between external stimulus to epigenetics modulation.
Cells transmit extracellular information from the membrane to the nucleus which involves using cell-surface receptors and signaling pathways. By utilizing growth factor signaling pathways, gene expression can be controlled via the extracellular environment, but the involvement of chromatin regulators is largely unknown.
My work focus on uncovering the contribution of mixed lineage leukemias (MLLs) histone methyltransferase complex in cell signaling regulation via stimulus induce methlytransferase recruitment. While cancers have a high frequency of somatic alterations on chromatin regulators and growth factor signaling pathways, affecting the regulate interactions of epigenetics regulation in cell signaling events. By understanding the mechanism of stimulus induce methlytransferase recruitment, which may lead to potential new therapeutic targets.
Recently, I am exploring the effects of histone methyltransferase on the tumor immune microenvironment.
Featured Publications
COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection.
Summary of COVID-19 vaccines update in 2022 about vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection.
wei-yu-chi
Recent Publications
(2026).
MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1 dependent TGF-β signaling.
Genes Dev..
(2017).
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Nature Communications, 8(465).
Recent & Upcoming Talks
15th Workshop Epigenetics@DKFZ
Oral Presentation at the section of Chromatin features and their function
Recent News
DKTK working group: Translational Epigenetics & Novel Pharmacological Modalities
Thanks for presenting my work in the working group.
2024 Max Planck Freiburg Epigenetics Meeting
Great research conference right at my black forest home.
Mert Bozkurt did a great ERAMUS+ research internship at Marc Timmers Lab
It's happy to work together with Mert
Gordon Research Conference for Histone and DNA Modifications
A week travel to go deep into histone modifications
BioMed X Boot Camp: Complex Human Ex Vivo Models of Tissue Inflammation
A week of brainstroming and pharmaceutical mindset on research and developement.
Back to iGEM competition as a judge
Judging the world biggest synthetic biology competition in Paris
FASEB Research Conference: TGF-β superfamily signaling in development and disease
Happy to travel to Malahide, Ireland for TGF-β Research Conference with the travel award.
EMBL-EBI workshop: Introduction to multiomics data integration and visualisation
While travel is complicate, the bioinformatics workshop is happening online.