Professional Summary

Timothy En Haw Chan is a scientist working on understanding epigenetics regulation in cancer and cell signaling, focuses on the interplay of external stimulus to cellular epigenetic regulation. Expertise in information curation, data analysis and synthesis idea. Passionate to summarize discoveries, biotech industry development and communicating science in biomedical field. He lived in Malaysia, Taiwan, Germany and traveled to more than 60 countries. Other than research, he is a contributing writer/columnist and science outreach educator.

Education

PhD Biology

2018-09-01
2026-03-31

Max Planck IMPRS-IEM PhD Program & University of Freiburg, Germany

MS Biomedical Sciences

2016-09-01
2018-08-15

Chang Gung University, Taiwan

BSc Biomedical Sciences

2012-09-01
2016-06-28

Chang Gung University, Taiwan

Interests

Epigenetics Cancer Biology Signaling Transduction Synthetic Biology
📚 My Research 🧬

Elucidating interplays between external stimulus to epigenetics modulation.

Cells transmit extracellular information from the membrane to the nucleus which involves using cell-surface receptors and signaling pathways. By utilizing growth factor signaling pathways, gene expression can be controlled via the extracellular environment, but the involvement of chromatin regulators is largely unknown.

My work focus on uncovering the contribution of mixed lineage leukemias (MLLs) histone methyltransferase complex in cell signaling regulation via stimulus induce methlytransferase recruitment. While cancers have a high frequency of somatic alterations on chromatin regulators and growth factor signaling pathways, affecting the regulate interactions of epigenetics regulation in cell signaling events. By understanding the mechanism of stimulus induce methlytransferase recruitment, which may lead to potential new therapeutic targets.

Recently, I am exploring the effects of histone methyltransferase on the tumor immune microenvironment.

Featured Publications
COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection. featured image

COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection.

Summary of COVID-19 vaccines update in 2022 about vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection.

wei-yu-chi
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism featured image

APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

Genetic deletion polymorphism of APOBEC3A DNA editing enzyme as a oral cancer biomarker.

ting-wen-chen
Recent Publications
(2026). MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1 dependent TGF-β signaling. (In Press).
(2022). COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection.. JBS.
(2017). APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. Nature Communications, 8(465).
Recent & Upcoming Talks
15th Workshop Epigenetics@DKFZ featured image

15th Workshop Epigenetics@DKFZ

Oral Presentation at the section of Chromatin features and their function

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Timothy En Haw Chan
Recent News
DKTK working group: Translational Epigenetics & Novel Pharmacological Modalities featured image

DKTK working group: Translational Epigenetics & Novel Pharmacological Modalities

Thanks for presenting my work in the working group.

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Timothy En Haw Chan
2024 Max Planck Freiburg Epigenetics Meeting featured image

2024 Max Planck Freiburg Epigenetics Meeting

Great research conference right at my black forest home.

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Timothy En Haw Chan
Mert Bozkurt did a great ERAMUS+ research internship at Marc Timmers Lab featured image

Mert Bozkurt did a great ERAMUS+ research internship at Marc Timmers Lab

It's happy to work together with Mert

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Timothy En Haw Chan
Gordon Research Conference for Histone and DNA Modifications featured image

Gordon Research Conference for Histone and DNA Modifications

A week travel to go deep into histone modifications

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Timothy En Haw Chan
BioMed X Boot Camp: Complex Human Ex Vivo Models of Tissue Inflammation featured image

BioMed X Boot Camp: Complex Human Ex Vivo Models of Tissue Inflammation

A week of brainstroming and pharmaceutical mindset on research and developement.

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Timothy En Haw Chan
Back to iGEM competition as a judge featured image

Back to iGEM competition as a judge

Judging the world biggest synthetic biology competition in Paris

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Timothy En Haw Chan
FASEB Research Conference: TGF-β superfamily signaling in development and disease featured image

FASEB Research Conference: TGF-β superfamily signaling in development and disease

Happy to travel to Malahide, Ireland for TGF-β Research Conference with the travel award.

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Timothy En Haw Chan
EMBL-EBI workshop: Introduction to multiomics data integration and visualisation featured image

EMBL-EBI workshop: Introduction to multiomics data integration and visualisation

While travel is complicate, the bioinformatics workshop is happening online.

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Timothy En Haw Chan