MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1 dependent TGF-β signaling
January 17, 2026·
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Timothy En Haw Chan
Md Saiful Islam
Omid Fotouhi
Mert Bozkurt
Nizamuddin Sheikh
Katrin Schüle
Sebastian J Arnold
H. T. Marc Timmers
Abstract
Transforming growth factor β (TGF-β) signaling is a highly pleiotropic pathway with an important role in development, homeostasis and cancer. Chromatin regulators contribute to the regulation of TGF-β responsive transcription. Requirement of subunits of the MLL3/MLL4 histone methyltransferase complexes for TGF-β responses have been reported. However, their exact roles are not fully understood.
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*(In Press)
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Scientist - Biotech Editor
Timothy En Haw Chan is a scientist working on understanding epigenetics regulation in cancer and cell signaling, focuses on the interplay of external stimulus to cellular epigenetic regulation. Expertise in information curation, data analysis and synthesis idea. Passionate to summarize discoveries, biotech industry development and communicating science in biomedical field. He lived in Malaysia, Taiwan, Germany and traveled to more than 60 countries. Other than research, he is a contributing writer/columnist and science outreach educator.
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